Comparative Genomic Hybridization Analysis of Nonfunctioning Pituitary Tumors1

Comparative Genomic Hybridization (CGH)

Comparative genomic hybridization analysis of adrenocortical tumors of childhood.

Although several genes have been investigated in adrenal tumorigenesis, the genetic background of adrenocortical tumors (ACT) remains poorly characterized. In southern Brazil, the annual incidence of ACT is unusually high, ranging from 3.4-4.2/million children, compared with a worldwide incidence of 0.3/million children younger than 15 yr. Environmental factors have been implicated because the ...

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors.

Comparative genomic hybridization produces a map of DNA sequence copy number as a function of chromosomal location throughout the entire genome. Differentially labeled test DNA and normal reference DNA are hybridized simultaneously to normal chromosome spreads. The hybridization is detected with two different fluorochromes. Regions of gain or loss of DNA sequences, such as deletions, duplicatio...

Computational Methods for the Analysis of Array Comparative Genomic Hybridization

Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of high throughput data, which in turn has prompted the development of computational strategies for the analysis of array CGH data. Here we explain the principles behind array image processing, data visua...

comparative genomic hybridization analysis of fetal samples arising from recurrent spontaneous abortion

objective: this study determined the chromosomal constitution of recurrent spontaneous abortions by comparative genomic hybridization (cgh) analysis of fetal samples. material and methods:   forty pregnant women with early recurrent pregnancy losses aged 21 to 42 years old from tehran university of medical sciences affiliated hospitals entered in this descriptive study. hibridization analysis o...